Thymol and eugenol derivatives as potential antileishmanial agents

9-Anilinoacridines as potential antileishmanial agents.

A number of 1'-substituted 9-anilinoacridines were evaluated for their activities against promastigote and amastigote forms of Leishmania major and for their toxicities to human Jurkat leukemia cells. Several compounds possessing 1'-NH-alkyl substituents produced more than 80% growth inhibition of macrophage-infected L. major amastigotes at or below a concentration of 1 microM. 1'-Hexylamino-9-...

4-amino bis-pyridinium derivatives as novel antileishmanial agents.

The antileishmanial activity of a series of bis-pyridinium derivatives that are analogues of pentamidine have been investigated, and all compounds assayed were found to display activity against promastigotes and intracellular amastigotes of Leishmania donovani and Leishmania major, with 50% effective concentrations (EC50s) lower than 1 μM in most cases. The majority of compounds showed similar ...

Evaluation of bactericidal activity of thymol-eugenol solution as a potential disinfectant agent

Aim: The emergence of nosocomial infections, which are mainly transmitted by contaminated instruments, there is an urgent need of a novel disinfecting agent, which can able to act by the novel method with less residual concentration. Evaluation of antibacterial activity of thymol-eugenol mixture for potential application as disinfectant agent. Methods: The reference strains of Escherichia coli,...

Glucan and Tuftsin - Potential Antileishmanial Agents

1,3‐Bis(aryloxy)propan‐2‐ols as potential antileishmanial agents

We describe herein the synthesis and antileishmanial activity of 1,3-bis(aryloxy)propan-2-ols. Five compounds (2, 3, 13, 17, and 18) exhibited an effective antileishmanial activity against stationary promastigote forms of Leishmania amazonensis (IC50  < 15.0 μm), and an influence of compound lipophilicity on activity was suggested. Most of the compounds were poorly selective, as they showed tox...